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Merck - 475838-50MG - Mifepristone | CAS 84371-65-3 | Calbiochem | 50MG

  • MFR SKU: 475838-50MG
  • ITEM #: 6281229
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ITEM #: 6281229
A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors.
This listing is for 50 mg Plastic ampoule

Merck - 475838-50MG - Mifepristone | CAS 84371-65-3 | Calbiochem | 50MG

  • Item #: 6281229
  • MFR SKU: 475838-50MG
  • Overview A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Inhibits P-glycoprotein (P-gp) function and down-modulates P-gp mediated drug resistance. Displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Regulates the expression of Fas and FasL in mouse endometrium and TRAIL in prostate cancer cells. As an antioxidant, it offers neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H 2 O 2 -, and glutamate-induced injury to mouse hippocampal HT22 cells.
  • Catalogue Number 475838
  • Brand Family Calbiochem®
  • Synonyms (11β, 17β)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4, 9-dien-3-one, RU-486
  • References McCullers, D.L., et al. 2002. Neuroscience 109, 219.
  • Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci. 955, 159.
  • Gao, F., et al. 2001. Acta Pharmacol. Sin. 22, 524.
  • Hyder, S.M., et al. 2001. Int. J. Cancer 92, 469.
  • Lam, F.C., et al. 2001. J. Neurochem . 76, 1121.
  • Sridhar, S., et al. 2001. Cancer Res. 61, 7179.
  • Behl, C., et al. 1997. Eur. J. Neurosci. 9, 912.
  • Greb, R.R., et al. 1997. Hum. Reprod. 12, 1280.
  • Gruol, D.J., et al. 1994. Cancer Res. 54, 3088.
  • CAS number 84371-65-3
  • ATP Competitive N
  • Form Yellow solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Progesterone and glucocorticoid receptors
  • Purity ≥ 99% by titration
  • Cell permeable Y
  • Contaminants Steroid substances: ≤ 0.1%
  • RTECS KG2955000
  • R Phrase R: 60-61
  • May impair fertility.
  • May cause harm to the unborn child.
  • S Phrase S: 22-36/37/39-45
  • Do not breathe dust.
  • Wear suitable protective clothing, gloves and eye/face protection.
  • In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
  • Ship Code Ambient Temperature Only
  • Toxicity Carcinogenic / Teratogenic
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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