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Merck - 475889-5MG - MK-886 | CAS 118414-82-7 | Calbiochem | 5MG

  • MFR SKU: 475889-5MG
  • ITEM #: 3442134
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ITEM #: 3442134
A cell-permeable, orally active NSAID that blocks cellular Cox pathway PGE2 production by inhibiting COX-1 and mPGES-1, but not COX-2, activity, as well as suppresses cellular 5-LO pathway activation by inhibiting FLAP, rather than 5-LO, activity.
This listing is for 5 mg Plastic ampoule

Merck - 475889-5MG - MK-886 | CAS 118414-82-7 | Calbiochem | 5MG

  • Item #: 3442134
  • MFR SKU: 475889-5MG
  • Overview A cell-permeable, orally active NSAID (nonsteroidal antiinflammatory drug) that blocks cellular Cox pathway PGE2 (prostaglandin E 2 ) production by inhibiting COX-1 and mPGES-1 (microsomal PGE 2 synthase-1), but not COX-2, activity (IC 50 = 8, 2, and 58 µ M, respectively), as well as suppresses cellular 5-LO (5-Lypoxygenase; Cat. No. 437996 ) pathway activation by inhibiting FLAP (5-LO-activating protein), rather than 5-LO, activity (
  • Primary Target IC<sub> 50</sub> 102 nM
  • Purity ≥ 99% by TLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +15° C to +30° C
  • Do not freeze Ok to freeze
  • Special Instructions Unstable in solution; reconstitute just prior to use.

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