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Merck - 475957-10MG - c-Myc Inhibitor II | CAS 413611-93-5 | Calbiochem | 10 MG

  • MFR SKU: 475957-10MG
  • ITEM #: 6295729
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ITEM #: 6295729
The c-Myc Inhibitor II, also referenced under CAS 413611-93-5, controls the biological activity of c-Myc.
This listing is for 10 mg

Merck - 475957-10MG - c-Myc Inhibitor II | CAS 413611-93-5 | Calbiochem | 10 MG

  • Item #: 6295729
  • MFR SKU: 475957-10MG
  • Overview A cell-permeable benzoxadiazole compound that is shown to preferentially disrupt the interactions of c-Myc-Max, Mad1-Max, and Myf5-HEB, over those of 31 other pairs of HLH-, ZIP-, and HLH-ZIP-containing proteins. Similarly to 10058-F4 (Cat. No. 475956 ), 10074-G5 is shown to selectively inhibit the c-Myc-dependent growth of rat fibroblast cell line TGR1 and effectively suppress c-Myc-dependent transcription activity. Binding studies using various mutated and truncated c-Myc constructs reveal that 10074-G5 targets c-Myc helix-1 region between aa residues 363 and 381 (K D = 4.4 µ M), while 10058-F4 interaction site is located within aa residues 402 through 412 (K D = 13 µ M).
  • Catalogue Number 475957
  • Brand Family Calbiochem®
  • Synonyms 7-Nitro-N-(2-phenylphenyl)-2, 1, 3-benzoxadiazol-4-amine, Biphenyl-2-yl-(7-nitrobenzo[1, 2, 5]oxadiazol-4-ylamine, 10074-G5
  • References Follis, A.V., et al. 2008. Chem. Biol. 15, 1149.
  • Yin, X., et al. 2003. Oncogene 22, 6151.
  • Sold under license of U.S. Patent 7, 026, 343.
  • CAS number 413611-93-5
  • Form Deep orange solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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