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Merck - 475992-10MG - mTOR Inhibitor XII, Torin2 - Calbiochem

Name: Merck - 475992-10MG - mTOR Inhibitor XII, Torin2 - Calbiochem
SKU: 475992-10MG
Price: 399.5 USD
Availability: InStock

$399.50

Stock Status: SHIPS SOON (reserve your unit today)
Average lead time for this brand: 2-3 weeks. Specific products may vary.

ITEM #: 13025330
mTOR Inhibitor XII, Torin2
, 10MG
This listing is for Each

Overview A Torin1 (Cat. No. 475991 ) structural analog that acts as a cell-permeable, potent, ATP-competitive inhibitor against DNA-PK and mTOR (IC 50 = 0.5 and 2.81 nM, respectively). Comparing to Torin1, Torin2 displays enhanced inhibitory potency against PI 4-Kβ (IC 50 = 18.3 nM) and PI 3-K (IC 50 =4.68, 5.67, 8.58, 17.5, 24.5, and 28.1 nM, respectively, against P110α/P85α, P110γ, hVPS34, P110δ/P85α, C2β, C2α, respectively), while being more effective in inhibiting S6K1 Thr389 phosphorylation in MEF cultures (IC 50 = 0.25 nM vs 2 nM, respectively, for Torin2 and Torin1) in vitro and displaying much improved oral bioavailability in mice ( C max (ng/mL) / T 1/2 (h) = 3968/0.72 and 223/0.79, respectively, for Torin2 and Torin1; 10 /mg/kg p.o.) in vivo .
Catalogue Number 475992
Brand Family Calbiochem®
Synonyms 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1, 6]naphthyridin-2(1H)-one, DNA-PK Inhibitor VII, PI 3-K Inhibitor XIX, PI 4-K Inhibitor
References Liu, Q., et al. 2011. J Med Chem. 54, 1473.
Liu, Q., et al. 2010, J Biol Chem. 284, 8023.
Form Yellow powder
Hill Formula CHFNO

Chemical formula CHFNO
Reversible Y
Structure formula Image
Quality Level MQ100
Primary Target MTOR 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"

br> Primary Target IC<sub> 50</sub> 2 nM
Purity ≥ 99% by HPLC
Cell permeable Y
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2° C to +8° C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
Packaged under inert gas Packaged under inert gas

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