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Merck - 479975-250MG - NDGA | CAS 500-38-9 | Calbiochem | 250MG

  • MFR SKU: 479975-250MG
  • ITEM #: 3035183
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ITEM #: 3035183
NDGA, Larrea divaricata^ (Nordihydroguaiaretic acid). An antioxidant and a selective lipoxygenase (LOX) inhibitor over cyclooxygenase (IC50=100uM). Purity: >=90% by HPLC. Soluble in DMSO and ethanol. CAS: 500-38-9. FW: 302.4. Crystalline solid, 250mg.
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Merck - 479975-250MG - NDGA | CAS 500-38-9 | Calbiochem | 250MG

  • Item #: 3035183
  • MFR SKU: 479975-250MG
  • Overview A cell-permeable antioxidant and a selective lipoxygenase (LOX) inhibitor (IC 50 = 200 nM, 30 µ M, and 30 µ M for 5-LOX, 12-LOX, and 15-LOX, respectively) over cyclooxygenase (IC 50 = 100 µ M). Also shown to inhibit platelet-derived growth factor (PDGF)-stimulated DNA synthesis in Swiss/3T3 cells. A powerful hydroxy radical quencher.
  • Catalogue Number 479975
  • Brand Family Calbiochem®
  • Synonyms Nordihydroguaiaretic Acid
  • References Domin, J., et al. 1994. J. Biol. Chem. 269, 8260.
  • Goodman, Y., et al. 1994. Brain Res. 654, 171.
  • Kozubik, A., et al. 1993. Exp. Hematol. 21, 138.
  • Salari, H., et al. 1984. Prostagland. Leuk. Med. 13, 53.
  • Hope, W.C., et al. 1983. Biochem. Pharmacol. 32, 367.
  • CAS number 500-38-9
  • ATP Competitive N
  • Form Crystalline solid
  • Hill Formula CHO
  • Chemical formula CHO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target LOX-5 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 200 nM, 30 µ M, and 30 µ M for 5-LOX, 12-LOX, and 15-LOX, respectively
  • Purity ≥ 90% by HPLC
  • Cell permeable Y
  • RTECS UX1750000
  • R Phrase R: 22-36/37/38
  • Harmful if swallowed.
  • Irritating to eyes, respiratory system and skin.
  • S Phrase S: 26-36
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Harmful
  • Storage +15° C to +30° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.

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