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Merck - 481908-2MG - Nicotinamide Phosphoribosyltransferase Inhibitor, FK866 | CAS 658084-64-1 | Calbiochem | 2MG

  • MFR SKU: 481908-2MG
  • ITEM #: 11575494
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ITEM #: 11575494
The Nicotinamide Phosphoribosyltransferase Inhibitor, FK866, also referenced under CAS 658084-64-1, controls the biological activity of Nicotinamide Phosphoribosyltransferase. This small molecule/inhibitor is primarily used for Neuroscience applications.
This listing is for 2 mg

Merck - 481908-2MG - Nicotinamide Phosphoribosyltransferase Inhibitor, FK866 | CAS 658084-64-1 | Calbiochem | 2MG

  • Item #: 11575494
  • MFR SKU: 481908-2MG
  • Overview A cell-permeable pyridinylacrylamide compound that acts as a selective, allosteric NAPRT/NAMPT (nicotinamide phosphoribosyltransferase) inhibitor (K i = 0.4 nM for the enzyme/substrate complex; K i ′ = 0.3 nM for the free enzyme), while exhibiting no effect toward NPRT (nicotinic acid phosphoribosyltransferase) activity (82% inhibition of NAPRT activity at 10 nM vs no inhibition of NPRT activity at 1 µ M in K-562 extract). FK866 treatment is shown to induce cell death by depleting NAD + (Cat. Nos. 481911 & 481915 ) in HepG2 and NIH-3T3 cultures (by >95% after 24 h treatment of 10 nM FK866), likewise the addition of exogenous NAD + is demonstrated to rescue NIH-3T3 and SH-SY5Y from FK866-induced NAD + -depletion and cell death.
  • Catalogue Number 481908
  • Brand Family Calbiochem®
  • Synonyms NAPRT Inhibitor, (E) -N-(4-(1-Benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide, NAMPT Inhibitor, APO866, NAMPTase Inhibitor I, PBEF Inhibitor I, Visfatin Inhibitor I
  • References Formentini, L., et al. 2009. Biochem. Pharmacol. 77, 1612.
  • Nakahata, Y., et al. 2009. Science 324, 654.
  • Ramsey. K.M., et al. 2009. Science 324, 651.
  • Billington, R.A., et al. 2008. J. Biol. Chem. 283, 6367.
  • Hasmann, M. and Schemainda, I., 2003. Cancer Res. 63, 7436.
  • CAS number 658084-64-1
  • Form Colorless to yellow liquid
  • Formulation Supplied as a 50 mM (2 mg/102.17 µl) solution in DMSO.
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 97% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Packaged under inert gas Packaged under inert gas

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