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Merck - 496000-250UG - InSolution OM99-2 | CAS 314266-76-7 | Calbiochem | 250UG

  • MFR SKU: 496000-250UG
  • ITEM #: 6281101
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ITEM #: 6281101
An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2.
This listing is for 250 μg Plastic ampoule

Merck - 496000-250UG - InSolution OM99-2 | CAS 314266-76-7 | Calbiochem | 250UG

  • Item #: 6281101
  • MFR SKU: 496000-250UG
  • Overview An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2 (K i = 1.6 nM, recombinant memapsin 2; K i = 9.58 nM, recombinant pro-memapsin 2). Also inhibits cathepsin D (K i = 48 nM). This aspartyl protease inhibitor is designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement; also includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala.
  • Catalogue Number 496000
  • Brand Family Calbiochem®
  • Synonyms EVNLΨ AAEF
  • References Ghosh, A.K., et al. 2001. J. Med. Chem. 44, 2865.
  • Turner III, R.T., et al. 2001. Biochemistry 40, 10001.
  • Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522.
  • Hong, L., et al. 2000. Science 290, 150.
  • CAS number 314266-76-7
  • ATP Competitive N
  • Form Liquid
  • Formulation A 1 mM (250µg in 280 µl) solution in DMSO. Supplied as a trifluoroacetate salt.
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target human brain memapsin 2 i $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target K i " value=" Biological Information"
  • br> Primary Target K<sub>i</sub> 1.6 nM against recombinant memapsin 2; 9.58 nM against recombinant pro-memapsin 2; 48 nM against cathepsin D
  • Purity ≥ 90% by HPLC
  • Cell permeable N
  • Peptide Sequence Glu-Val-Asn-Leu-Ψ-Ala-Ala-Glu-Phe [Ψ denotes replacement of CONH by (S)-CH(OH)CH]
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Protect from Moisture Protect from moisture
  • Do not freeze Ok to freeze
  • Special Instructions Following initial thaw, aliquot and freeze (-20° C). Avoid freeze/thaw cycles of solutions.
  • Packaged under inert gas Packaged under inert gas

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