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Merck - 496265-25MG - Oncrasin-1 | CAS 75629-57-1 | Calbiochem | 25MG

  • MFR SKU: 496265-25MG
  • ITEM #: 11575525
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ITEM #: 11575525
A cell-permeable indolecarboxaldehyde compound that selectively induces apoptosis in cells harboring mutant K-Ras both in vitro and in vivo .
This listing is for 25 mg Plastic ampoule

Merck - 496265-25MG - Oncrasin-1 | CAS 75629-57-1 | Calbiochem | 25MG

  • Item #: 11575525
  • MFR SKU: 496265-25MG
Technical Specs
  • Overview A cell-permeable indolecarboxaldehyde compound that selectively induces apoptosis in cells harboring mutant K-Ras both in vitro (IC 50 = 0.11, 0.25, 1.0, 1.58, and 4.81 µ M in H2887, H460, H2122, A549, and T29Kt1 cultures, respectively) and in vivo (75% suppression of H460-derived tumor growth in mice; 100 mg/kg via daily i.p.), while exhibiting little or much reduced potency toward cells with wild-type Ras or mutant N-Ras (IC 50 ≥ 31 µ M). Oncrasin-1 treatment is shown to induce PKCι aggregation with splicing factors in the nucleus and dissociation between PKCι and CDK9/Cyclin T1 in K-Ras mutant cultures, resulting in decreased RNA polymerase II phosphorylation and a suppression of RNA processing in general. Oncrasin-1-induced cell death requires the presence of both mutant K-Ras and PKCι, siRNA-mediated knockdown of either enzyme is demonstrated to abolish its cytotoxicity in H460 and T29Kt1 cultures.
  • Catalogue Number 496265
  • Brand Family Calbiochem®
  • Synonyms 1-((4-Chlorobenzyl)-1H-indole-3-carboxaldehyde, Onc ogenic Ras Tumor- In hibiting compound 1
  • References Guo, W., et al. 2009. Mol. Cancer Ther. 8, 441.
  • Guo, W., et al. 2008. Cancer Res. 68, 7403.
  • CAS number 75629-57-1
  • Form Off-white to light pink solid
  • Hill Formula CHClNO
  • Chemical formula CHClNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • R Phrase R: 36/38
  • Irritating to eyes and skin.
  • S Phrase S: 26-36-45
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
  • Ship Code Ambient Temperature Only
  • Toxicity Irritant
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas
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