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Merck - 5000059020 - NICOTINIC ACID EXTRA PU (20KG) (Each)

  • MFR SKU: 5000059020
  • ITEM #: 7029623
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ITEM #: 7029623
Nicotinic acid extra pure PH EUR, BP, USP^
This listing is for Each

Merck - 5000059020 - NICOTINIC ACID EXTRA PU (20KG) (Each)

  • Item #: 7029623
  • MFR SKU: 5000059020
  • Catalogue Number 500005
  • Synonyms Niacin, 3-Pyridinecarboxylic acid
  • Nicotinic acid
  • CAS number 59-67-6
  • EC number 200-441-0
  • Grade Ph Eur, BP, USP
  • Hill Formula CHNO
  • Chemical formula 3-(COOH)-CHN
  • Molar Mass 123.11 g/mol
  • HS Code 2936 29 00
  • Structure formula Image
  • Quality Level MQ400
  • Density 1.473 g/cm3 (25 ° C)
  • Flash point 193 ° C
  • Ignition temperature >365 ° C Dust
  • Melting Point 236.6 ° C
  • pH value 3.4 (10 g/l, HO, 20 ° C)
  • Bulk density 330 kg/m3
  • Solubility 18 g/l
  • LD 50 oral LD50 Rat > 5000 mg/kg
  • LD 50 dermal LD50 Rat > 2000 mg/kg
  • Hazard Pictogram(s)
  • Hazard Statement(s) H319: Causes serious eye irritation.
  • Precautionary Statement(s) P264: Wash skin thoroughly after handling.
  • P280: Wear eye protection/ face protection.
  • P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P337 + P313: If eye irritation persists: Get medical advice/ attention.
  • Signal Word Warning
  • Storage class 10 - 13 Other liquids and solids
  • WGK WGK 1 slightly hazardous to water
  • Disposal 4
  • Liquid organic acids or solutions should be diluted, if necessary, and carefully neutralized with sodium hydrogen carbonate (Cat. No. 106323) or with sodium hydroxide (Cat. No 106462). Before filling into container D, check the pH with pH universal indicator strips (Cat. No. 109535).
  • Categories of danger irritant
  • Storage Store at +15° C to +25° C.
  • Declaration (railroad and road) ADR, RID Kein Gefahrgut
  • Declaration (transport by air) IATA-DGR No Dangerous Good
  • Declaration (transport by sea) IMDG-Code No Dangerous Good
  • Assay (alkalimetric, calculated on dried substance) 99.5 - 100.5 %
  • Assay (HPLC, calculated on dried substance) 98.0 - 102.0 %
  • Identity (HPLC) passes test
  • Identity (IR-spectrum) passes test
  • Identity (Melting point) passes test
  • Identity (UV-absorption) passes test
  • Appearance white to almost white, crystalline powder
  • Melting point 234 - 240 ° C
  • Absorption ratio (A 237 / A 262) 0.46 - 0.50
  • Chloride (Cl) ≤ 200 ppm
  • Sulfate (SO) ≤ 200 ppm
  • As (Arsenic) ≤ 3 ppm
  • Pb (Lead) ≤ 10 ppm
  • Cu (Copper)* ≤ 25 ppm
  • Cu (Copper) (ICP)* ≤ 25 ppm
  • Pd (Palladium)* ≤ 1 ppm
  • Zn (Zinc) ≤ 25 ppm
  • Residual solvents (ICH Q3C) excluded by production process
  • Related substances (HPLC) (largest single impurity) ≤ 0.05 %
  • Related substances (HPLC, Ph Eur) (sum of all impurities) ≤ 0.05 %
  • Related substances (HPLC) (Isocinchomeronic acid) ≤ 0.05 %
  • Related substances (HPLC) (6-Hydroxynicotinic acid) ≤ 0.05 %
  • Related substances (HPLC) (Isonicotinic acid) ≤ 0.05 %
  • Related substances (HPLC) (6-Methylnicotinic acid) ≤ 0.05 %
  • Related substances (HPLC) (6, 6‘-Dinicotinic acid) ≤ 0.05 %
  • Related substances (HPLC) (5-Nitronicotinic acid) ≤ 0.05 %
  • Related substances (HPLC) (Pyridine) ≤ 0.05 %
  • Related substances (HPLC) (3-Nitropyridine) ≤ 0.05 %
  • Related substances (HPLC) (3, 5-Dinitropyridine) ≤ 0.05 %
  • Related substances (HPLC) (3-Ethylpyridine) ≤ 0.05 %
  • Related substances (HPLC) (5-Ethyl-2-methylpyridine) ≤ 0.05 %
  • Related substances (HPLC) (any unspecified impurity) ≤ 0.05 %
  • Related substances (HPLC, USP) (sum of all impurities) ≤ 0.20 %
  • Sulfated ash (600° C) ≤ 0.1 %
  • Loss on drying (105° C, 1h) ≤ 1.0 %
  • Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
  • Corresponds to Ph Eur, BP, USP

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