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Merck - 5001110100 - Cocarboxylase tetrahydrate

  • MFR SKU: 5001110100
  • ITEM #: 17954933
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ITEM #: 17954933
(thiamine diphosphoric acid ester tetrahydrate) EMPROVE® API
This listing is for 100 g Plastic bottle

Merck - 5001110100 - Cocarboxylase tetrahydrate

  • Item #: 17954933
  • MFR SKU: 5001110100
  • Catalogue Number 500111
  • CAS number 68684-55-9
  • EC number 205-230-7
  • Hill Formula CHNOPS * 4 HO
  • Molar Mass 496.37 g/mol
  • HS Code 2936 22 00
  • Structure formula Image
  • Quality Level MQ600
  • pH value 2.4 - 3.2 (100 g/l, HO, 20 ° C)
  • Bulk density 450 kg/m3
  • Solubility 55 g/l
  • Storage class 10 - 13 Other liquids and solids
  • WGK WGK 1 slightly hazardous to water
  • Storage Store at +2° C to +25° C.
  • Assay (HPLC, anhydrous substance) 96.0 - 101.0 %
  • Identity (IR-spectrum) passes test
  • pH-value (10%; water) 2.4 - 3.2
  • Chloride (Cl) (Ion Chromatography) ≤ 0.025 %
  • Free phosphate (PO) ≤ 1.0 %
  • Al (Aluminium) (#) ≤ 0.0010 %
  • As (Arsenic) ≤ 0.0003 %
  • Ni (Nickel) (#) ≤ 0.0002 %
  • Thiamine phosphoric acid ester (HPLC) ≤ 1.5 %
  • Thiamin (HPLC) ≤ 0.1 %
  • Dithiamintriphosphate (HPLC) ≤ 0.25 %
  • Impurity A (HPLC) ≤ 0.1
  • Impurity B (HPLC) ≤ 0.1
  • Related substances (HPLC) ≤ 1.5 %
  • Water 14.0 - 16.5 %
  • Endotoxins < 12
  • Residual Solvents of class 3 ((2-Propanol) according to ICH Q3C) ≤ 0.2 %
  • Other residual solvents (according to ICH Q3C) excluded by manufacturing process
  • Microbiological test passes test
  • Colony count (aerobic bacteria (TAMC)) ≤ 1000 CFU/g
  • Colony count (Yeasts and moulds (TYMC)) ≤ 100 CFU/g
  • E.coli passes test
  • Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities).
  • Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (#).
  • Residues of metal or metal reagents acc. to EMEA/CHMP/SWP/ 4446/2000 are not likely to be present.

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