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Merck - 5001120100 - Cocarboxylase chloride

  • MFR SKU: 5001120100
  • ITEM #: 17954944
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ITEM #: 17954944
(thiamine diphosphoric acid ester chloride) EMPROVE® API
This listing is for 100 g Plastic bottle

Merck - 5001120100 - Cocarboxylase chloride

  • Item #: 17954944
  • MFR SKU: 5001120100
  • Catalogue Number 500112
  • Synonyms Thiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP
  • CAS number 154-87-0
  • EC number 205-836-1
  • Hill Formula CHClNOPS
  • Molar Mass 460.80 g/mol
  • HS Code 2936 22 00
  • Structure formula Image
  • Quality Level MQ600
  • Melting Point 240 - 244 ° C (decomposition)
  • pH value 2.2 (HO)
  • Bulk density 500 kg/m3
  • Solubility 220 g/l
  • Hazard Pictogram(s)
  • Hazard Statement(s) H317: May cause an allergic skin reaction.
  • Precautionary Statement(s) P261: Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
  • P272: Contaminated work clothing should not be allowed out of the workplace.
  • P280: Wear protective gloves.
  • P302 + P352: IF ON SKIN: Wash with plenty of water.
  • P333 + P313: If skin irritation or rash occurs: Get medical advice/ attention.
  • P362 + P364: Take off contaminated clothing and wash it before reuse.
  • Signal Word Warning
  • RTECS XI7552000
  • Storage class 10 - 13 Other liquids and solids
  • WGK WGK 1 slightly hazardous to water
  • Storage Store at +2° C to +25° C.
  • Assay (HPLC, calc. on dried substance) ≥ 93.0 %
  • Appearance (color) white
  • Appearance (description) crystalline powder
  • Identity (IR-spectrum) conforms
  • Identity (Cl) passes test
  • Appearance of solution (10%; water) clear, < colour reference solution Y7
  • pH-value (10%; water) 1.0 - 1.4
  • Chloride (Cl) (calculated on dried substance) 7.5 - 7.9 %
  • Free phosphate (PO) ≤ 1.0 %
  • Sulfate (SO) ≤ 0.01 %
  • Al (Aluminium) (#) ≤ 0.0010 %
  • As (Arsenic) ≤ 0.0003 %
  • Ni (Nickel) (#) ≤ 0.0002 %
  • Thiamin Monophosphoric Acid Ester Chloride (HPLC) ≤ 4.0 %
  • Thiamin Dichloride (HPLC) ≤ 0.5 %
  • Dithiamintriphosphate (HPLC) ≤ 0.20 %
  • Impurity A (HPLC) ≤ 0.1
  • Impurity B (HPLC) ≤ 0.1
  • Related substances (HPLC) ≤ 1.5 %
  • Loss on drying (130° C) ≤ 1.5 %
  • Endotoxins ≤ 12 I.U./g
  • Microbiological test passes test
  • Colony count (aerobic bacteria (TAMC)) ≤ 500 CFU/g
  • Colony count (Yeasts and moulds (TYMC)) ≤ 100 CFU/g
  • Salmonella species In 10g substance not detectable
  • E.coli In 1g substance not detectable
  • Staphylococcus aureus In 1g substance not detectable
  • Pseudomonas aeruginosa In 1g substance not detectable
  • Candida albicans In 1g substance not detectable
  • Residual solvents (Ph Eur/USP/ICH) class2 (Methanol) ≤ 2.0 %
  • Other residual solvents (Ph Eur/USP/ICH) excluded by manufacturing process
  • Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities).
  • Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (#).
  • Residues of metal or metal reagents acc. to EMEA/CHMP/SWP/ 4446/2000 are not likely to be present.

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