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Merck - 506168-25MG - p53 Activator VII, STIMA-1 | CAS 91634-12-7 | Calbiochem | 25MG

  • MFR SKU: 506168-25MG
  • ITEM #: 6295731
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ITEM #: 6295731
The p53 Activator VII, STIMA-1, also referenced under CAS 91634-12-7, modulates the biological activity of p53. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
This listing is for 25 mg

Merck - 506168-25MG - p53 Activator VII, STIMA-1 | CAS 91634-12-7 | Calbiochem | 25MG

  • Item #: 6295731
  • MFR SKU: 506168-25MG
  • Overview A cell-permeable styrylquinazoline compound that preferentially induces apoptotic death of mutant p53-harboring H1299-His175 and Saos-2-His273 tumor cells (IC 50 = 3.4 and 4.9 µ M, respectively), while exhibiting much reduced potency towards p53-null (IC 50 = 9.6, 11.4, and 14.7 µ M against H1299, Saos-2, and HCT116, respectively) or wild-type p53-expressing (IC 50 = 13.2 and 20.3 µ M against HCT116 and HDF, respectively) cells. STIMA-1 is demonstrated to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax.
  • Catalogue Number 506168
  • Brand Family Calbiochem®
  • Synonyms 2-Vinyl-1H-quinazolin-4-one, S H group T argeting and I nduction of M assive A poptosis
  • References Zache, N., et al. 2008. Mol. Oncol. 2, 70.
  • CAS number 91634-12-7
  • Form Off-white solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 1 week at -20° C. Prepare fresh as required.
  • Packaged under inert gas Packaged under inert gas

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