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Merck - 506181-500UG - p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 | Calbiochem | 500UG

  • MFR SKU: 506181-500UG
  • ITEM #: 6281352
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ITEM #: 6281352
p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, acts as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion & postnatal cerebellar neurons.
This listing is for 500 μg Plastic ampoule

Merck - 506181-500UG - p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 | Calbiochem | 500UG

  • Item #: 6281352
  • MFR SKU: 506181-500UG
  • Overview The p75 NTR inhibitor Pep5 (Cat. No. 506180 ) is made cell-permeable by fusing it with the N-terminal protein transduction domain sequence (11 amino acids) from HIV protein TAT. Shown to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in both DRG (dorsal root ganglion) and postnatal cerebellar neurons. A potential therapeutic agent against inhibition of regeneration in the central nervous system.
  • Catalogue Number 506181
  • Brand Family Calbiochem®
  • Synonyms TAT-Pep5, H- YGRKKRRQRRR -CFFRGGFFNHNPRYC-OH, Cyclic
  • References Yamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461.
  • Schwarze, S.R., et al. 1999. Science 285, 1569.
  • ATP Competitive N
  • Form Lyophilized solid
  • Formulation Supplied as a trifluoroacetate salt.
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Hygroscopic Hygroscopic
  • Reversible N
  • Quality Level MQ100
  • Application p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, acts as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion & postnatal cerebellar neurons.
  • Primary Target Blocker of MAG- and Nogo-induced inhibition of neurite outgrowth
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • Peptide Sequence HN- Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg -Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²-OH
  • disulfide bond (12-26)
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 1 month at -20° C.
  • Packaged under inert gas Packaged under inert gas

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