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Merck - 516561-50UG - Pertussis Toxin, Bordetella pertussis, Glycerol Solution - CAS 70323-44-3 - Calbiochem

MFR SKU: 516561-50UG

ITEM #: 6280836

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ITEM #: 6280836
Pertussis Toxin, Bordetella pertussis , Glycerol Solution, CAS 70323-44-3, is a protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins.
This listing is for 50 μg Alu drum

Merck - 516561-50UG - Pertussis Toxin, <i>Bordetella pertussis, </i> Glycerol Solution - CAS 70323-44-3 - Calbiochem

Item #: 6280836

MFR SKU: 516561-50UG

Technical Specs

Overview A protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins. The holotoxin has five dissimilar subunits S-1, S-2, S-3, S-4, and S-5, in a molar ratio of 1:1:1:2:1, S-1 (A protomer) is responsible for the enzymatic activity of the toxin, and S-2, S-3, S-4, and S-5 form the B oligomer which is responsible for the toxins binding to the cell surface. NOTE: This product is not activated, hence for use in cell-free systems, activation is required.
Catalogue Number 516561
Brand Family Calbiochem®
Synonyms Islet-activating Protein
References Fryer, M.W. 1992. Neurosci. Lett. 146, 84.
Gierschik, P. 1992. Curr. Topics Microbiol. Immunol. 175, 69.
Harada, J., et al. 1992. Eur. J. Pharmacol. 227, 301.
Hausman, S.Z., and Burns, D.L. 1992. J. Biol. Chem. 267, 13735.
Kaslow, H.R., and Burns, D.L. 1992. FASEB J. 6, 2684.
Zhu, J., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1479
Kaslow, H.R., et al. 1987. Biochemistry 26, 123.
Hewlett, E.L., et al. 1983. Infect. Immun. 40, 1198.
Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.
CAS number 70323-44-3
Activity ≤ 35 pmol/min/µg in the presence of 1 µ M calmodulin
ATP Competitive N
Form Liquid
Formulation In 500 mM NaCl, 50 mM Tris, 10 mM glycine, 50% glycerol, pH 7.5.
Reversible N
Quality Level MQ200
Biological activity ≤ 1 ng/ml as determined in a clustering assay using CHO cells line
Primary Target Guanine nucleotide-binding regulatory proteins 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"

br> Primary Target IC<sub> 50</sub> ≤ 1 ng/ml as determined in a clustering assay using CHO cells line
Purity Five distinct bands by SDS-PAGE
Concentration Label Please refer to vial label for lot-specific concentration
Cell permeable N
Contaminants Adenylate cyclase.
RTECS XW5883750
R Phrase R: 23/24/25
Toxic by inhalation, in contact with skin and if swallowed.
S Phrase S: 36/37/39-45
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Ship Code Blue Ice Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20° C
Do not freeze Ok to freeze
Special Instructions A uniform suspension may be achieved by gentle mixing prior to use.
Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.

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