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Merck - 516562-50UG - Pertussis Toxin, Salt-Free, Bordetella pertussis - CAS 70323-44-3 - Calbiochem

MFR SKU: 516562-50UG

ITEM #: 7010217

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ITEM #: 7010217
Pertussis Toxin, Salt-Free, Bordetella pertussis , CAS 70323-44-3, is a protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins.
This listing is for 50 μg Alu drum

Merck - 516562-50UG - Pertussis Toxin, Salt-Free, <i>Bordetella pertussis</i> - CAS 70323-44-3 - Calbiochem

Item #: 7010217

MFR SKU: 516562-50UG

Technical Specs

Overview A protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins. The holotoxin has five dissimilar subunits S-1, S-2, S-3, S-4, and S-5, in a molar ratio of 1:1:1:2:1, S-1 (A protomer) is responsible for the enzymatic activity of the toxin, and S-2, S-3, S-4, and S-5 form the B oligomer which is responsible for the toxins binding to the cell surface. NOTE: This product is not activated, hence for use in cell-free systems, activation is required.
Catalogue Number 516562
Brand Family Calbiochem®
Synonyms Islet-activating Protein
References Fryer, M.W. 1992. Neurosci. Lett. 146, 84.
Gierschik, P. 1992. Curr. Topics Microbiol. Immunol. 175, 69.
Harada, J., et al. 1992. Eur. J. Pharmacol. 227, 301.
Hausman, S.Z., and Burns, D.L. 1992. J. Biol. Chem. 267, 13735.
Kaslow, H.R., and Burns, D.L. 1992. FASEB J. 6, 2684.
Zhu, J., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1479.
Kaslow, H.R., et al. 1987. Biochemistry 26, 123.
Hewlett, E.L., et al. 1983. Infect. Immun. 40, 1198.
Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.
CAS number 70323-44-3
ATP Competitive N
Form Salt-free lyophilized solid
Reversible N
Quality Level MQ100
Biological activity ≤ 0.01 ng/ml. The activity is defined as the lowest concentration that promotes a clustering pattern in the CHO cell assay

Primary Target ADP-ribosylation of guanine nucleotide-binding regulatory proteins
Purity Five distinct bands by SDS-PAGE
Cell permeable N
RTECS XW5883750
R Phrase R: 23/24/25
Toxic by inhalation, in contact with skin and if swallowed.
S Phrase S: 36/37/39-45
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2° C to +8° C
Do not freeze Yes
Special Instructions Following reconstitution, store in the refrigerator (4° C). For long term storage in solution, reconstitute with a high ionic strength buffer, such as 100 mM sodium phosphate, 500 mM sodium chloride, pH 7.0. Stock solutions are stable for up to 6 months for use in CHO cell assays and for up to 2 months for use in non-cellular systems.
Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.

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