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Merck - 525145-1MG - sPLA-IIA Inhibitor I - Calbiochem

  • MFR SKU: 525145-1MG
  • ITEM #: 6281110
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ITEM #: 6281110
The sPLA-IIA Inhibitor I controls the biological activity of sPLA-IIA. This small molecule/inhibitor is primarily used for Cell Signaling applications.
This listing is for 1 mg Plastic ampoule

Merck - 525145-1MG - sPLA-IIA Inhibitor I - Calbiochem

  • Item #: 6281110
  • MFR SKU: 525145-1MG
  • Overview A highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of sPLA 2 -IIA (human type IIA secreted phospholipase A 2 ; IC 50 = 12.8 μ M). Shown to effectively block sPLA 2 -IIA-induced PGE 2 production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 μ M. Does not have any significant effect on the activities of porcine sPLA 2 -IB, Naja naja sPLA 2 -IB, or Crotalus durissus sPLA 2 -IIA even at 10 μ M concentration.
  • Catalogue Number 525145
  • Brand Family Calbiochem®
  • Synonyms c(2NapA)LS(2NapA)R, TFA
  • References Church, W.B., et al. 2001. J. Biol. Chem. 276, 33156.
  • ATP Competitive N
  • Form White lyophilized solid
  • Formulation Supplied as a trifluoroacetate salt.
  • Hill Formula CHNO · CFCOH
  • Chemical formula CHNO · CFCOH
  • Hygroscopic Hygroscopic
  • Reversible N
  • Quality Level MQ100
  • Primary Target sPLA2-IIA (human type IIA secreted phospholipase A2 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 12.8 µ M against sPLA2-IIA (human type IIA secreted phospholipase A2
  • Purity ≥ 95% by HPLC
  • Cell permeable N
  • Peptide Sequence cyclic(2-NaphthylAla-Leu-Ser-2-NaphthylAla-Arg)• TFA
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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