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Merck - 526523-5MG - PIM1/2 Kinase Inhibitor V | CAS 327033-36-3 | Calbiochem | 5 MG

  • MFR SKU: 526523-5MG
  • ITEM #: 11575763
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ITEM #: 11575763
The PIM1/2 Kinase Inhibitor V, also referenced under CAS 327033-36-3, controls the biological activity of PIM1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
This listing is for 5 mg Plastic ampoule

Merck - 526523-5MG - PIM1/2 Kinase Inhibitor V | CAS 327033-36-3 | Calbiochem | 5 MG

  • Item #: 11575763
  • MFR SKU: 526523-5MG
  • Overview A cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC 50 = 24 nM and 100 nM against Pim-1 and Pim-2, respectively), while exhibiting little or no activity against a panel of 58 other kinases (≤ 20% inhibition at 5 µ M). One hour inhibitor treatment (0.5 µ M) of HEK-293T cultures at the end of a 4 hour 32 PO 4 incubation period results in nearly complete inhibition of the autophosphorylation of overexpressed Pim-1. Comparing to Inhibitor VI (Cat. No. 526524 ), Inhibitor V is less reactive towards DYRK1α (20% vs. 68% inhibition with respective inhibitor at 5 µ M) and more potent in PC3 human prostate cancer cell killing (IC 50 = 17 vs. 48 µ M with respective inhibitor).
  • Catalogue Number 526523
  • Brand Family Calbiochem®
  • Synonyms (Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2, 4-dione, SMI-4a
  • References Lin, Y., et al. 2009. Blood In press.
  • Xia, Z., et al. 2009. J. Med. Chem. 52, 74.
  • CAS number 327033-36-3
  • Form Light beige solid
  • Hill Formula CHFNOS
  • Chemical formula CHFNOS
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 1 month at -20° C.
  • Packaged under inert gas Packaged under inert gas

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