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Merck - 528110-50MG - PIH | CAS 737-86-0 | Calbiochem | 50MG

  • MFR SKU: 528110-50MG
  • ITEM #: 6281102
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ITEM #: 6281102
A cell-permeable, non-toxic tridendate iron (Fe3+) chelator of the aroyl hydrazone class.
This listing is for 50 mg Plastic ampoule

Merck - 528110-50MG - PIH | CAS 737-86-0 | Calbiochem | 50MG

  • Item #: 6281102
  • MFR SKU: 528110-50MG
  • Overview A cell-permeable, non-toxic tridendate iron (Fe 3+ ) chelator of the aroyl hydrazone class. Even at low concentrations, highly effective in mobilizing Fe 3+ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Deferoxamine Mesylate (Cat. No. 252750 ) but has greater access to mitochondrial iron. Also useful for the management of iron overload disease in experimental models. Inhibits the induction of heme containing indoleamine 2, 3-dioxygenase activity.
  • Catalogue Number 528110
  • Brand Family Calbiochem®
  • Synonyms pyridoxal isonicotinoyl hydrazone, Iron Chelator III
  • References Buss, J.L., et al. 2002. Biochem. Pharmacol. 64, 1689.
  • Thomas, S.R., et al. 2001. J. Immunol. 166, 6332.
  • Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta 1523, 154.
  • Blaha, K., et al. 1998. Blood 11, 4368.
  • Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med. 131, 306.
  • Richardson, D.R., et al. 1995. Blood 86, 4295.
  • Richardson, D.R., et al. 1994. J. Lab. Clin. Med. 124, 660.
  • Ponka, P., et al. 1988. Biochim. Biophys. Acta 967, 122.
  • Ponka, P., et al. 1984. Biochim. Biophys. Acta 802, 477.
  • Ponka, P., et al. 1979. FEBS Lett. 97, 317.
  • CAS number 737-86-0
  • Form Yellow solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 99% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). DMSO stock solutions are stable for up to 6 months at -20° C. Acidic stock solutions are stable for up to 2 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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