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Merck - 528150-5MG - PARP Inhibitor VIII, PJ34 | CAS 344458-15-7 | Calbiochem | 5MG

  • MFR SKU: 528150-5MG
  • ITEM #: 3450289
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ITEM #: 3450289
PJ34^ 5mg. Off-white solid. Protect from light. Hygroscopic. Packaged under inert gas. Cell-permeable water-soluble phenanthridinone-derivative acting as potent inhibitor of poly(ADP-ribose) polymerase. About 10, 000x more potent than 3-Aminobenzamide. Purity: >=98% HPLC. Soluble in water. MW 331.8.
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Merck - 528150-5MG - PARP Inhibitor VIII, PJ34 | CAS 344458-15-7 | Calbiochem | 5MG

  • Item #: 3450289
  • MFR SKU: 528150-5MG
  • Overview A cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC 50 = 20 nM). Shown to be about 10, 000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350 ; EC 50 = 200 µ M). Does not act as an antioxidant at higher concentrations (1 µ M to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H 2 O(Cat. No. 528151 ).
  • Catalogue Number 528150
  • Brand Family Calbiochem®
  • References Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
  • Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
  • Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.
  • CAS number 344458-15-7
  • ATP Competitive N
  • Form White solid
  • Hill Formula CHNO · HCl
  • Chemical formula CHNO · HCl
  • Hygroscopic Hygroscopic
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Application PARP Inhibitor VIII, PJ34, CAS 344458-15-7, is a cell-permeable, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM).
  • Primary Target PARP 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> EC50 = 20 nM inhibiting poly(ADP-ribose) polymerase (PARP)
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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