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Merck - 529606-1MG - InSolution PP1 Analog II, 1NM-PP1 | CAS 221244-14-0 | Calbiochem | 1 MG

  • MFR SKU: 529606-1MG
  • ITEM #: 13025581
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ITEM #: 13025581
InSolution PP1 Analog II
, 1NM-PP1 | CAS 221244-14-0 | Calbiochem | 1 MG
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Merck - 529606-1MG - InSolution PP1 Analog II, 1NM-PP1 | CAS 221244-14-0 | Calbiochem | 1 MG

  • Item #: 13025581
  • MFR SKU: 529606-1MG
  • Overview A cell-permeable and reversible PP1 analog ( Cat. No. 529579 ) that acts as a potent, selective, and ATP-competitive inhibitor of mutant kinases compared to the corresponding wild-type kinase (IC 50 = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µ M for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µ M for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µ M for CDK2; 8 nM for F89G, CAMK IIa-as1 vs. 24 µ M for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µ M for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase.
  • Catalogue Number 529606
  • Brand Family Calbiochem®
  • Synonyms 4-Amino-1- tert -butyl-3-(1-naphthylmethyl)pyrazolo[3, 4-d]pyrimidine
  • References Ira, G., et al. 2004. Nature 431, 1011.
  • Papa, F.R., et al. 2003. Science 302, 1533.
  • Bishop, A.C., et al. 2000. Nature 407, 395.
  • Weiss, E.L., et al. 2000. Nat. Cell Biol. 2, 677.
  • Bishop, A.C., et al. 1999. J. Am. Chem. Soc. 121, 627.
  • CAS number 221244-14-0
  • Form Liquid
  • Formulation A 10 mM (1 mg/302 µ L) solution of PP1 Analog II, 1NM-PP1 ( Cat. No. 529581 ) in DMSO.
  • Hill Formula CHN
  • Hygroscopic Hygroscopic
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target mutant c-Fyn, v-src, Cadk2, CaMKIIa, c-Abl etc., 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µ
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • R Phrase R: 36/38
  • Irritating to eyes and skin.
  • S Phrase S: 36-45
  • Wear suitable protective clothing.
  • In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
  • Ship Code Dry Ice Only
  • Toxicity Irritant
  • Storage ≤ -70° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Avoid freeze/thaw Avoid freeze/thaw
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Aliquots are stable for up to 3 months at -70° C.
  • Packaged under inert gas Packaged under inert gas

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