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Merck - 529625-1MG - Polyphosphoinositide-Binding Peptide, PBP10 | Calbiochem | 1MG

  • MFR SKU: 529625-1MG
  • ITEM #: 3450403
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ITEM #: 3450403
Indicator Polyphosphoinositide^ Polyphosphoinositide-Binding Peptide, PBP10, Rho-B-Gln-Arg-Leu-Phe-Gln-Val-Lys-Gly-Arg-Arg-OH, Purity: =95% by HPLC. 1mg
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Merck - 529625-1MG - Polyphosphoinositide-Binding Peptide, PBP10 | Calbiochem | 1MG

  • Item #: 3450403
  • MFR SKU: 529625-1MG
  • Overview A Rhodamine-B-labeled decapeptide derived from the (PIP 2 )-binding region in segment-2 of gelsolin. Acts as a cell-permeable, reversible, and non-toxic agent that transiently disrupts actin filaments, which are essential for cell morphology and cell motility (~1-10 µ M). Specifically binds to polyphosphoinositide (PPI) with high affinity and activates platelet without significantly affecting intracellular Ca 2+ influx. Undergoes a reduction in fluorescence intensity upon binding to phosphatidylinositol 4, 5-bisphosphate (PIP 2 ) and lysophosphatidic acid; the fluorescence is not affected in the presence of phosphatidylserine and phosphatidylcholine. Useful fluorescent probe for the cellular localization and stabilization of PPIs.
  • Catalogue Number 529625
  • Brand Family Calbiochem®
  • Synonyms RhoB-GS 160-169 , Rhodamine B-QRLFQVKGRR-OH
  • References Bucki, R., et al. 2001. Biochemistry 40, 15752
  • Cunningham, C.C., et al. 2001. J. Biol. Chem. 276, 43390.
  • ATP Competitive N
  • Form Pinkish red lyophilized solid
  • Formulation Supplied as a trifluoroacetate salt.
  • Hill Formula CHNO
  • Hygroscopic Hygroscopic
  • Reversible Y
  • Quality Level MQ100
  • Primary Target Specifically binds to polyphosphoinositide (PPI)
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • Emission max.
  • Excitation max.
  • Peptide Sequence Rho-B-Gln-Arg-Leu-Phe-Gln-Val-Lys-Gly-Arg-Arg-OH
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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