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Merck - 530070-5MG - Pristimerin | CAS 1258-84-0 | Calbiochem | 5MG

  • MFR SKU: 530070-5MG
  • ITEM #: 11592163
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ITEM #: 11592163
A cell-permeable plant dienone-phenolic triterpenoid, naturally isolated from tripterygium wilfordii .
This listing is for 5 mg Plastic ampoule

Merck - 530070-5MG - Pristimerin | CAS 1258-84-0 | Calbiochem | 5MG

  • Item #: 11592163
  • MFR SKU: 530070-5MG
  • Overview A cell-permeable plant dienone-phenolic triterpenoid, naturally isolated from tripterygium wilfordii , whose inhibitory activities against proteasome chymotrypsin subunit (IC 50 = 2.2 and 3.0 µ M against purified rabbit 20S and human 26S proteasome, respectively) and cellular NF-κ B pathway/IKK activation most likely account for its reported anticancer efficacy both in vitro (IC 50 ≤ 610 nM in A549, K562, KBM5, MCF-7, MDA-MB-231, HepG2, and primary human leukemia cell cultures) and in mice in vivo (1 to 2.5 mg/kg/day, s.c.), including imatinib/STI571-resistant cancer cells harboring Bcr-Abl T315I mutation. Also reported to inhibit the activity of monoacylglycerol lipase (MGL), the enzyme that hydrolyzes and deactivates the cannabionoid receptor ligand 2-Arachidonoyl- sn -glycerol (2-AG), in a reversible manner with high potency (IC 50 = 93 nM).
  • Catalogue Number 530070
  • Brand Family Calbiochem®
  • Synonyms Monoacylglycerol Lipase Inhibitor II, Proteasome Inhibitor XV, NF-κ B Activation Inhibitor IX, MAGL Inhibitor II
  • References Lu, Z., et al. 2010. Mol. Cancer 9, 112.
  • King, A.R., et al. 2009. Chem. Biol. 16, 1045.
  • Tiedemann, R.E., et al. 2009. Blood 113, 4027.
  • Yang, H., et al. 2008. J. Cell. Biochem. 103, 234.
  • Wu, C.C., et al. 2005. Mol. Cancer Ther. 4, 1277.
  • CAS number 1258-84-0
  • Form Red solid
  • Hill Formula CHO
  • Chemical formula CHO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • S Phrase S: 20-24/25-36/37/39
  • When using do not eat or drink.
  • Avoid contact with skin and eyes.
  • Wear suitable protective clothing, gloves and eye/face protection.
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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