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Merck - 553400-500UG - Radicicol, Diheterospora chlamydosporia | CAS 12772-57-5 | Calbiochem | 500UG

  • MFR SKU: 553400-500UG
  • ITEM #: 7010079
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ITEM #: 7010079
Radicicol, Diheterospora chlamydosporia^ 500ug pkg'd under inert gas. Faint yellow solid. Antifungal macrocyclic lactone antibiotic acting as protein tyrosine kinase inhibitor. Inhibits p60v-src kinase activity & expression of COX-2. Purity:>97% TLC. CAS 12772-57-5.
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Merck - 553400-500UG - Radicicol, Diheterospora chlamydosporia | CAS 12772-57-5 | Calbiochem | 500UG

  • Item #: 7010079
  • MFR SKU: 553400-500UG
Technical Specs
  • Overview A cell-permeable, ATP-site binding, and irreversible antifungal macrocyclic lactone antibiotic that acts as a protein tyrosine kinase inhibitor. Inhibits p60 v- src kinase activity (IC 50 = 0.27 nM). Inhibits the expression of COX-2 (IC 50 = 27 nM) without affecting COX-1 expression in LPS-stimulated macrophages. Disrupts K-Ras-activated signaling pathways by selectively depleting Raf kinase. Inhibits tyrosine phosphorylation of p53/56 lyn in LPS-stimulated macrophages. Suppresses NIH/3T3 cell transformation by diverse oncogenes such as src, ras, and mos in part by blocking the key signal transduction intermediates such as MAP kinase and GAP-associated p62. Also exhibits anti-angiogenic activity in vivo . Inhibits Wnt-5A expression in dermal papilla cells (IC 50 = 190 nM).
  • Catalogue Number 553400
  • Brand Family Calbiochem®
  • References Shinonaga, H., et al. 2009. Bioorg. Med. Chem. 17, In press.
  • Soga, S., et al. 1998. J. Biol. Chem. 273, 822.
  • Chanmugam, P., et al. 1995. J. Biol. Chem. 270, 5418.
  • Shimada, Y., et al. 1995. J. Antibiot. 48, 824.
  • Zhao, J.F., et al. 1995. Oncogene 11, 161.
  • Oikawa, T., et al. 1993. Eur. J. Pharmacol. 241, 221.
  • Kwon, H.J., et al. 1992. Cancer Res. 52, 6926.
  • CAS number 12772-57-5
  • Form White solid
  • Hill Formula CHClO
  • Chemical formula CHClO
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target p60 v-src kinase activity 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 0.27 nM
  • Secondary target COX-2 (IC = 27 nM)
  • Purity ≥ 98% by HPLC
  • RTECS RR1105000
  • R Phrase R: 20/21/22-36/37/38
  • Harmful by inhalation, in contact with skin and if swallowed.
  • Irritating to eyes, respiratory system and skin.
  • S Phrase S: 26-36
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Harmful
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 1 month at -20° C.
  • Packaged under inert gas Packaged under inert gas
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