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Merck - 553514-10MG - RAD51 Inhibitor II, RI-1 | Calbiochem | 10 MG

  • MFR SKU: 553514-10MG
  • ITEM #: 11575889
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ITEM #: 11575889
RAD51 Inhibitor II, RI-1, CAS 415713-60-9, covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is needed for filament formation & recombinase activity.
This listing is for 10 mg Glass bottle

Merck - 553514-10MG - RAD51 Inhibitor II, RI-1 | Calbiochem | 10 MG

  • Item #: 11575889
  • MFR SKU: 553514-10MG
  • Overview A cell-permeable 1H-Pyrrole-2, 3-dione derivative that covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is essential for filament formation and recombinase activity. Stimulates single strand annealing at a 5-30 µ M concentration. Inhibits subnuclear RAD51 foci formation following DNA damage without affecting replication protein A. Also, effectively sensitizes cancer cells to mitomycin C (~25 µ M) and generate synergistic cell kill in RAD51C mutant cells and with lesser effect on RAD51 complemented cells. Satisfies all four Lipinski rules for predicting drug likeness.
  • Catalogue Number 553514
  • Brand Family Calbiochem®
  • Synonyms 3-chloro-1-(3, 4-dichlorophenyl)-4-morpholino-1H-pyrrole-2, 5-dione
  • References Budke, B., et al. 2012. Nucleic Acids Res. 40, 7347.
  • Form Bright yellow solid
  • Hill Formula CHClNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Application RAD51 Inhibitor II, RI-1, CAS 415713-60-9, covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is needed for filament formation & recombinase activity.
  • Primary Target RAD51 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 5-30 µ
  • Purity ≥ 99% by HPLC
  • Cell permeable Y
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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