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Merck - 554412-1MG - Tetrodotoxin, Citrate, Fugu sp. - CAS 18660-81-6 - Calbiochem

MFR SKU: 554412-1MG

ITEM #: 3441697

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ITEM #: 3441697
Tetrodotoxin, Fugu sp.^ (TTx). Crystalline solid. Contains sodium citrate. Soluble in H2O. RTECS IO1450000, CAS 4368-28-9, M.W. 319.3. A product of the Fisheries Research Institute of Hebei Province, People'' s Republic of China. WARNING! Toxic. LD50 of

Merck - 554412-1MG - Tetrodotoxin, Citrate, <i>Fugu </i>sp. - CAS 18660-81-6 - Calbiochem

Item #: 3441697

MFR SKU: 554412-1MG

Technical Specs

Overview Reversibly blocks Na + channels, which are essential for the propagation of impulses in excitable membranes. Useful as a marker of Na + channels in excitable tissues. Inhibits the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca 2+ accumulation (IC 50 = 63 nM).
Catalogue Number 554412
Brand Family Calbiochem®
Synonyms TTx
References Lysko, P.G., et al. 1994. Stroke 25, 2476.
Hu, S.L. and Kao, C.Y. 1985. Toxicon 23, 723.
Nakamura, M. and Yasumoto, T. 1985. Toxicon 23, 271.
CAS number 18660-81-6
ATP Competitive N
Declaration Not available for sale outside of the United States.
Form White solid
Formulation Crystalline solid. Contains sodium citrate.
Hill Formula CHNO
Chemical formula CHNO
Reversible Y
Quality Level MQ100
Application Tetrodotoxin, Fugu sp., CAS 18660-81-6, is a reversible blocker of Na+ channels. Inhibits the release of glutamate via Na+-dependent glutamate transporter.
Primary Target Na+ channels 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"

br> Primary Target IC<sub> 50</sub> 63 nM Iinhibiting the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation

Purity ≥ 98%
Cell permeable N
RTECS IO1450000
R Phrase R: 28
Very toxic if swallowed.
S Phrase S: 22-36/37/39-45
Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2° C to +8° C
Do not freeze Ok to freeze
Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C. Activity is destroyed if exposed to alkaline or strongly acidic conditions.
End use certificate Y

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