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Merck - 554718-5MG - REV-ERBalpha Antagonist, SR8278 | Calbiochem | 5MG

  • MFR SKU: 554718-5MG
  • ITEM #: 11575896
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$269.00
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ITEM #: 11575896
The REV-ERBα Antagonist, SR8278 controls the biological activity of REV-ERBα.
This listing is for 5 mg Glass bottle

Merck - 554718-5MG - REV-ERBalpha Antagonist, SR8278 | Calbiochem | 5MG

  • Item #: 11575896
  • MFR SKU: 554718-5MG
  • Overview A cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC 50 = 0.47 µ M) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC 50 = 0.35 µ M) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µ M results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.
  • Catalogue Number 554718
  • Brand Family Calbiochem®
  • Synonyms SR8278 SR 8278
  • References Kojetin, D., et al. 2010, Chem Bio in press
  • Form White to yellow-brown solid or gum
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Structure formula Image
  • Quality Level MQ100
  • Purity >95% by HPLC
  • Ship Code Shipped with Blue Ice or with Dry Ice
  • Toxicity Regulatory Review
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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