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Merck - 554995-10MG - RGS Proteins Inhibitor II, CCG-50014 | Calbiochem | 10 MG

  • MFR SKU: 554995-10MG
  • ITEM #: 11575898
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ITEM #: 11575898
The RGS Proteins Inhibitor II, CCG-50014 controls the biological activity of RGS4 proteins. This small molecule/inhibitor is primarily used for Biochemicals applications.
This listing is for 10 mg Glass bottle

Merck - 554995-10MG - RGS Proteins Inhibitor II, CCG-50014 | Calbiochem | 10 MG

  • Item #: 11575898
  • MFR SKU: 554995-10MG
  • Overview A cell-permeable thiadiazolidinedione compound that acts as a direct, potent, selective and cysteine-reactive irreversible inhibitor of RGS4 over other RGS proteins (IC 50 = 0.03, 0.12, 3.5, 11, > 200 and > 200 µ M against RGS4, RGS19, RGS16, RGS8, RGS7 and RGS4Cys − using FCPIA assay, respectively). Shown to block RGS4-Gα 0 interaction and repress Gα 0 -dependent membrane localization of RGS4 in HEK-293T cells with no effect on the intrinsic rate of GTP hydrolysis by Gα 0 . Suggested to interact with Cys 107 -RGS8 allosteric regulatory site and display minimal affinity towards papain (IC 50 > 100 µ M). A reversible inhibitor of RGS Proteins, CCG-63802 is also available (Cat. No. 554993 ).
  • Catalogue Number 554995
  • Brand Family Calbiochem®
  • Synonyms 4-(4-Fluorobenzyl)-2-p-tolyl-1, 2, 4-thiadiazolidine-3, 5-dione
  • References Blazer, L.L., et al. 2011. Biochemistry 50, 3181.
  • Roman, D.L., et al. 2009. J. Biomol. Screening 14, 610.
  • Form White solid
  • Hill Formula CHFNOS
  • Chemical formula CHFNOS
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 98% by HPLC
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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