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Merck - 555562-10MG - Rho Kinase Inhibitor XIII, RKI-1447 (ROCK) | Calbiochem | 10 MG

  • MFR SKU: 555562-10MG
  • ITEM #: 13047372
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ITEM #: 13047372
Rho Kinase Inhibitor XIII, RKI-1447 10MG
Rho Kinase Inhibitor XIII, RKI-1447 (ROCK) | Calbiochem | 10 MG
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Merck - 555562-10MG - Rho Kinase Inhibitor XIII, RKI-1447 (ROCK) | Calbiochem | 10 MG

  • Item #: 13047372
  • MFR SKU: 555562-10MG
  • Overview A cell-permeable pyridylthiazolyl-urea that acts as a potent, ATP site-targeting, Rho Kinase inhibitor (IC 50 = 14.5 and 6.2 nM against ROCK1 and ROCK2, respectively), displaying much reduced potency against PKA, PKN1/PRK1, p70S6K/RPS6kB1, AKT1, MRCKa/CDC42BPA (85.5%, 80.5%, 61.9%, 56.0%, and 50.4% inhibition, respectively, by 1 µ M RKI-1447) or 15 other kinases. Selectively inhibits ROCK-dependent, but not mTORC2-dependent, cellular phosphorylations (effective conc. 0.1 to 1 µ M in MDA-MB-231, MDA-MB-468, and H1299 cultures). Shown to be efficacious in suppressing established tumor expansion in a murine ErbB2 mammary cancer model (200 mg/kg/day i.p.) in vivo .
  • Catalogue Number 555562
  • Brand Family Calbiochem®
  • Synonyms 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea, Mesylate, 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea, Methanesulfonate, ROCK Inhibitor XIII
  • References Patel, R.A., et al. 2012. Cancer Res. 72, 5025.
  • Form Yellowish white solid
  • Hill Formula CHNOS • CHSOH
  • Chemical formula CHNOS • CHSOH
  • Hygroscopic Hygroscopic
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Rho kinases 1 & 2 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 14.5 and 6.2 nM against ROCK1 and ROCK2, respectively
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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