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Merck - 557330-5MG - Rolipram | CAS 61413-54-5 | Calbiochem | 5MG

  • MFR SKU: 557330-5MG
  • ITEM #: 4148027
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ITEM #: 4148027
Rolipram^ ( {4-[ 3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone}). Off-white solid. Selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 800 nM). A rolipram-insensitive PDE IV subtype is also known to exist. Purity: >= 98% by TLC. Soluble in DMSO.
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Merck - 557330-5MG - Rolipram | CAS 61413-54-5 | Calbiochem | 5MG

  • Item #: 4148027
  • MFR SKU: 557330-5MG
  • Overview A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC 50 = 800 nM). A rolipram-insensitive PDE IV subtype is also known to exist. Also inhibits NF-κ B and NFAT activation in Jurkat and primary T cells.
  • Catalogue Number 557330
  • Brand Family Calbiochem®
  • Synonyms 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
  • References Navarro, J., et al. 1998. J. Virol. 72, 4712.
  • Truong, V.H. and Muller, T. 1994. FEBS Lett. 353, 113.
  • Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther. 270, 250.
  • Moore, J.B., Jr., et al. 1991. Biochem. Pharmacol. 42, 679.
  • Reeves, M.L., et al. 1987. Biochem. J . 241, 535.
  • Schneider, H.H., et al. 1986. Eur. J. Pharmacol. 127, 105.
  • CAS number 61413-54-5
  • ATP Competitive N
  • Form White solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target PDE IV 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 800 nM against cAMP-specific phosphodiesterase (PDE IV)
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • RTECS UY5749237
  • R Phrase R: 36/37/38
  • Irritating to eyes, respiratory system and skin.
  • S Phrase S: 26-36
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Irritant
  • Storage +2° C to +8° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). DMSO stock solutions are stable for up to 6 months at -20° C.

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