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Merck - 557550-1MG - Ro106-9920 | CAS 62645-28-7 | Calbiochem | 1MG

  • MFR SKU: 557550-1MG
  • ITEM #: 6281242
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ITEM #: 6281242
A cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties.
This listing is for 1 mg Plastic ampoule

Merck - 557550-1MG - Ro106-9920 | CAS 62645-28-7 | Calbiochem | 1MG

  • Item #: 6281242
  • MFR SKU: 557550-1MG
  • Overview A cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties. Acts as a highly selective, irreversible inhibitor of Iκ Bαee ubiquitination (IC 50 = 2.3 µ M). Blocks NF-κ B-dependent cytokine expression in human PBMNs (IC 50 ’s = ~ 700 nM for TNF-α, IL-1β, and IL-6 inhibition) and rats. Does not inhibit SCF β TRCP (Iκ Bα ubiquitin ligase)-mediated β-catenin ubiquitination in Jurkat cells. At 10 µ M concentrations, also inhibits the activities of 5-lipoxygenase (by 89%) and EGFR kinase (by 63%).
  • Catalogue Number 557550
  • Brand Family Calbiochem®
  • References Swinney, D.C., et al. 2002. J. Biol. Chem. 277, 23573.
  • CAS number 62645-28-7
  • ATP Competitive N
  • Form White solid
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Iκ Bαee ubiquitination 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 2.3 µ M against Iκ Bαee ubiquitination
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • Ship Code Dry Ice Only
  • Toxicity Standard Handling
  • Storage ≤ -70° C
  • Protect from Light Protect from light
  • Protect from Moisture Protect from moisture
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-70° C). Stock solutions are stable for up to 3 months at -70° C.
  • Packaged under inert gas Packaged under inert gas

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