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Merck - 559303-5MG - SANT-1 | CAS 304909-07-7 | Calbiochem | 5MG

  • MFR SKU: 559303-5MG
  • ITEM #: 6281244
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ITEM #: 6281244
A potent, cell-permeable antagonist of the Shh signaling pathway by binding directly to Smoothened, a distant relative of G protein-coupled receptors.
This listing is for 5 mg Plastic ampoule

Merck - 559303-5MG - SANT-1 | CAS 304909-07-7 | Calbiochem | 5MG

  • Item #: 6281244
  • MFR SKU: 559303-5MG
  • Overview A potent, cell-permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway (IC 50 = 20 nM in the Shh-LIGHT2 assay and in Ptch1 -l- cells) by binding directly to Smoothened (Smo; K d = 1.2 nM), a distant relative of G protein-coupled receptors. Unlike cyclopamine (Cat. No. 239803 ), SANT-1 equipotently inhibits the activities of both wild-type and oncogenic Smo (IC 50 = 30 nM in SmoA1-LIGHT2 assay).
  • Catalogue Number 559303
  • Brand Family Calbiochem®
  • Synonyms Shh Signaling Antagonist V
  • References Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
  • Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
  • CAS number 304909-07-7
  • ATP Competitive N
  • Form White solid
  • Hill Formula CHN
  • Chemical formula CHN
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Shh (Sonic Hedgehog) signaling pathway 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 20 nM as antagonist of the Shh (Sonic Hedgehog) signaling pathway in the Shh-LIGHT2 assay and in Ptch1-l- cells
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • From Catalog: Desc. Field- added "cell-permeable
  • Packaged under inert gas Packaged under inert gas

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