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Merck - 565761-1MG - g-Secretase Inhibitor IV (gamma-secretase) | Calbiochem | 1MG

  • MFR SKU: 565761-1MG
  • ITEM #: 6281028
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ITEM #: 6281028
The γ-Secretase Inhibitor IV controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
This listing is for 1 mg Plastic ampoule

Merck - 565761-1MG - g-Secretase Inhibitor IV (gamma-secretase) | Calbiochem | 1MG

  • Item #: 6281028
  • MFR SKU: 565761-1MG
  • Overview A cell-permeable, reversible inhibitor of γ-secretase. Equipotently inhibits the release of Aβ x-40 (ED 50 = 2.6 µ M) and Aβ x-42 (ED 50 = 2.7 µ M) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.
  • Catalogue Number 565761
  • Brand Family Calbiochem®
  • Synonyms 2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal
  • References Green, K.N., et al. 2002. J. Physiol. 541.3, 1013.
  • Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
  • ATP Competitive N
  • Form White lyophilized solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible Y
  • Quality Level MQ100
  • Primary Target Aβ x-40 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> ED50 = 2.6 µ M for Aβx-40
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • Peptide Sequence 2-Naphthoyl-Val-Phe-CHO
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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