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Merck - 565770-5MG - g-Secretase Inhibitor IX (gamma-secretase) | CAS 208255-80-5 | Calbiochem | 5MG

  • MFR SKU: 565770-5MG
  • ITEM #: 3450398
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ITEM #: 3450398
gamma Secretase Inhibitor IX^ 5mg. DAPT. N-[N-(3, 5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester. Lyophilized solid. Dipeptide suppressing Ab prod. by blocking gamma secretase. Prevents Ab34 generation in murine N2a cells & hAPP/hBACE-1 transfected human HEK 293 cells. Purity>=95% HPLC
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Merck - 565770-5MG - g-Secretase Inhibitor IX (gamma-secretase) | CAS 208255-80-5 | Calbiochem | 5MG

  • Item #: 3450398
  • MFR SKU: 565770-5MG
Technical Specs
  • Overview A cell-permeable dipeptide that suppresses Aβ production by blocking γ-secretase (Aβ total IC 50 = 115 nM, Aβ 42 IC 50 = 200 nM). Prevents Aβ 34 generation in murine N2a cells and hAPP/hBACE-1 transfected human HEK 293 cells. Reported to be functionally active in both HEK 293 cells and neuronal cultures without affecting the secretion of amyloid-β precursor protein (APP). Also shown to lower Aβ levels acutely in APP-transgenic mice. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice. A 25 mM (5 mg/462 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565784 ) in DMSO is also available.
  • Catalogue Number 565770
  • Brand Family Calbiochem®
  • Synonyms DAPT, N-[N-(3, 5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t -Butyl Ester
  • References Morohashi, Y., et al. 2006. J. Bio. Chem. Vol. 281, 14670.
  • Nishitomo, K. et al. 2006 J. Neurochem. 99, 1555.
  • Oddo, S., et al. 2004. Neuron 43, 321.
  • Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
  • Sastre, M., et al. 2001. EMBO Rep. 2, 835.
  • Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
  • CAS number 208255-80-5
  • ATP Competitive N
  • Form Lyophilized
  • Hill Formula CHFNO
  • Chemical formula CHFNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Aβ total 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 115 nM suppressing Aβtotal production; 200 nM suppressing Aβ 42 production
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas
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