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Merck - 565773-5MG - g-Secretase Inhibitor XII (gamma-secretase) | Calbiochem | 5MG

  • MFR SKU: 565773-5MG
  • ITEM #: 6281121
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ITEM #: 6281121
γ-Secretase Inhibitor XII, is a cell-permeable, reversible inhibitor of γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in APP695 expressing CHO 2b-7 cells.
This listing is for 5 mg Plastic ampoule

Merck - 565773-5MG - g-Secretase Inhibitor XII (gamma-secretase) | Calbiochem | 5MG

  • Item #: 6281121
  • MFR SKU: 565773-5MG
  • Overview A cell-permeable, reversible dipeptide aldehyde that reduces Aβ production by blocking γ-secretase activity in vitro (Aβ 40 IC 50 = 7.9 µ M; Aβ 42 IC 50 = 7.6 µ M) and in cultured CHO 2b-7 cells that stably overexpress APP695 (Aβ 40 IC 50 = 11.5 µ M; Aβ 42 IC 50 = 8.3 µ M). Also blocks the generation of CTFγ (γ-secretase-generated carboxyl-terminal fragment). Does not affect the formation of amyloid-β-precursor protein (APP).
  • Catalogue Number 565773
  • Brand Family Calbiochem®
  • Synonyms Z-IL-CHO
  • References Weijzen, S., et al. 2002. Nat. Med. 8, 979.
  • McLendon, C., et al. 2000. FASEB J. 14, 2383.
  • ATP Competitive N
  • Form White solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Application γ-Secretase Inhibitor XII, is a cell-permeable, reversible inhibitor of γ-secretase activity in vitro (Aβ 40 IC50 = 7.9 µ M; Aβ 42 IC50 = 7.6 µ M) and in APP695 expressing CHO 2b-7 cells.
  • Primary Target Aβ 40 in vitro 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 7.9 µ M for Aβ 40; 7.6 µ M for Aβ 42 in vitro
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • Peptide Sequence Z-Ile-Leu-CHO
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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