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Merck - 565789-500UG - g-Secretase Inhibitor XX | CAS 209984-56-5 | Calbiochem | 500 UG

  • MFR SKU: 565789-500UG
  • ITEM #: 6281662
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ITEM #: 6281662
This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model.
This listing is for 500 μg Plastic ampoule

Merck - 565789-500UG - g-Secretase Inhibitor XX | CAS 209984-56-5 | Calbiochem | 500 UG

  • Item #: 6281662
  • MFR SKU: 565789-500UG
  • Overview A cell-permeable dibenzazepine (dbz) compound that acts as a potent γ-secretase inhibitor and significantly lowers both brain and plasma Aβ 40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 µmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC 50 = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and Apc Min mouse models (10 µmol/kg, i.p).
  • Catalogue Number 565789
  • Brand Family Calbiochem®
  • Synonyms (S, S)-2-[2-(3, 5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6, 7-dihydro-5H-dibenzo[b, d]azepin-7-yl)propionamide, DBZ, Dibenzazepine
  • References Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.
  • van Es, J.H., et al. 2005. Nature 435, 959.
  • Milano, J., et al. 2004. Toxicol. Sci. 82, 341.
  • CAS number 209984-56-5
  • ATP Competitive N
  • Form White solid
  • Hill Formula CHFNO
  • Chemical formula CHFNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target γ-secretase 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 1.7 nM inhibiting Notch processing in SupT1 cells
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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