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Merck - 567020-50MG - Simvastatin (MK-733) | CAS 79902-63-9 | Calbiochem | 50MG

  • MFR SKU: 567020-50MG
  • ITEM #: 3450121
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ITEM #: 3450121
A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation.
This listing is for 50 mg Plastic ampoule

Merck - 567020-50MG - Simvastatin (MK-733) | CAS 79902-63-9 | Calbiochem | 50MG

  • Item #: 3450121
  • MFR SKU: 567020-50MG
  • Overview A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca 2+ signaling and insulin secretion by blocking L-type Ca 2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: this product is supplied in an inactive form and requires treatment with NaOH in EtOH followed by neutralization to pH 7.2 for activation.
  • Catalogue Number 567020
  • Brand Family Calbiochem®
  • Synonyms MK-733, L-Type Calcium Channel Blocker VI
  • References Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
  • Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
  • Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
  • Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345 , 259.
  • Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
  • Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
  • CAS number 79902-63-9
  • ATP Competitive N
  • Form Off-white solid
  • Hill Formula CHO
  • Chemical formula CHO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target farnesylation
  • Purity ≥ 98% by HPLC
  • Cell permeable N
  • Contaminants Heavy metals:

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