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Merck - 567630-5GM - Sodium Salicylate (Salicylic Acid, Na) | CAS 54-21-7 | Calbiochem | 5GM

  • MFR SKU: 567630-5GM
  • ITEM #: 3030589
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ITEM #: 3030589
Sodium Salicylate^ Non-steroidal anti-inflammatory drug that interferes with TNF-induced NF-[kappa]B activation by inhibiting phosphorylation and subsequent degradation of the I[kappa]B-[alpha] protein. CAS: 54-21-7. FW: 160.1. Purity: >=98% by titration. Solubility: Ethanol, water. 5g white solid.
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Merck - 567630-5GM - Sodium Salicylate (Salicylic Acid, Na) | CAS 54-21-7 | Calbiochem | 5GM

  • Item #: 3030589
  • MFR SKU: 567630-5GM
  • Overview A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κ B activation by inhibiting phosphorylation and subsequent degradation of the Iκ B-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κ B activation.
  • Catalogue Number 567630
  • Brand Family Calbiochem®
  • Synonyms Salicylic Acid, Na, NaSal
  • References Schwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
  • Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
  • Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
  • Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
  • Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.
  • CAS number 54-21-7
  • ATP Competitive N
  • Form Off-white solid
  • Hill Formula CHO · Na
  • Chemical formula CHO · Na
  • Hygroscopic Hygroscopic
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases
  • Purity ≥ 98% by titration
  • Cell permeable Y
  • RTECS VO5075000
  • R Phrase R: 22
  • Harmful if swallowed.
  • S Phrase S: 24/25
  • Avoid contact with skin and eyes.
  • Ship Code Ambient Temperature Only
  • Toxicity Harmful
  • Storage +15° C to +30° C
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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