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Merck - 567727-1MG - D-erythro-Sphingosine-1-phosphate - CAS 26993-30-6 - Calbiochem

  • MFR SKU: 567727-1MG
  • ITEM #: 4147921
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ITEM #: 4147921
D-erythro-Sphingosine-1-phosphate^ White solid. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A putative second messenger that mobilizes calcium from intracellular stores via an IP3-independent pathway. Activates phospholipase D and inhibits chemotactic motility and invasiveness of tumor cells.
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Merck - 567727-1MG - D-<i>erythro-</i>Sphingosine-1-phosphate - CAS 26993-30-6 - Calbiochem

  • Item #: 4147921
  • MFR SKU: 567727-1MG
  • Overview A putative second messenger that mobilizes calcium from intracellular stores via an IP 3 -independent pathway. Activates phospholipase D (PLD) and inhibits chemotactic motility and invasiveness of tumor cells. Also stimulates growth of quiescent Swiss/3T3 fibroblasts. Inhibits activation of caspases that cleave PARP and lamins during Fas- and ceramide-mediated apoptosis.
  • Catalogue Number 567727
  • Brand Family Calbiochem®
  • References Cuvillier, O., et al. 1998. J. Biol. Chem . 273, 2910.
  • Mattie, M., et al. 1994. J. Biol. Chem. 269, 3181.
  • Olivera, A. and Spiegel, S. 1993. Nature 365, 557.
  • Desai, N.N., et al. 1992. J. Biol. Chem. 267, 23122.
  • Sadahira, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 9686.
  • CAS number 26993-30-6
  • ATP Competitive N
  • Form White solid
  • Hill Formula CHNOP
  • Chemical formula CHNOP
  • Hygroscopic Hygroscopic
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Mobilizes calcium from intracellular stores
  • Purity ≥ 95% by TLC
  • Cell permeable N
  • R Phrase R: 36/37/38
  • Irritating to eyes, respiratory system and skin.
  • S Phrase S: 26-36
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Irritant
  • Storage -20° C
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and evaporate under a stream of nitrogen. Store at -20° C. Prior to use, dissolve in 4 mg/ml BSA solution with vortexing. Stock solutions are stable for up to 2 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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