Image is an illustration, may not reflect the exact product sold.


Other products by Merck

Merck - 567731-10MG - Sphingosine Kinase Inhibitor | CAS 1177741-83-1 | Calbiochem | 10 MG

  • MFR SKU: 567731-10MG
  • ITEM #: 6281425
  • 0 Reviews / 0 Questions
$234.50
Stock Status: SHIPS SOON (reserve your unit today)
Average lead time for this brand: 2-3 weeks. Specific products may vary.

ITEM #: 6281425
The Sphingosine Kinase Inhibitor, also referenced under CAS 1177741-83-1, controls the biological activity of Sphingosine Kinase. This small molecule/inhibitor is primarily used for Cell Signaling applications.
This listing is for 10 mg Plastic ampoule

Merck - 567731-10MG - Sphingosine Kinase Inhibitor | CAS 1177741-83-1 | Calbiochem | 10 MG

  • Item #: 6281425
  • MFR SKU: 567731-10MG
  • Overview A cell-permeable disubstituted thiazole compound that displays anti-tumor properties. Acts as a potent, substrate competitive, reversible, and highly specific inhibitor of sphingosine kinase (IC 50 = 0.5 µ M for GST-hSK). Does not affect the kinase activity of hERK2, hPI3K, or PKCα even at concentrations as high as 60 µ M. Induces apoptosis in human cancer cells that express the drug transport proteins Pgp or MRP1 (IC 50 = ~ 1-5 µ M) through inhibiting sphingosine-1-phosphate production.
  • Catalogue Number 567731
  • Brand Family Calbiochem®
  • Synonyms 2-( p -Hydroxyanilino)-4-( p -chlorophenyl) thiazole, HCl, SK Inhibitor I
  • References French, K.J., et al. 2003. Cancer Res. 63, 5962.
  • CAS number 1177741-83-1
  • ATP Competitive Y
  • Form White solid
  • Hill Formula CHClNOS • HCl
  • Chemical formula CHClNOS • HCl
  • Hygroscopic Hygroscopic
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target GST-hsk 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 0.5 µ M for GST-hSK
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Carcinogenic / Teratogenic
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

There are no questions about this product yet. Be the first to ask a question.

0 out of 5 stars
5 Star
0 %
4 Star
0 %
3 Star
0 %
2 Star
0 %
1 Star
0 %

Review this product

Tell us about your personal experience

Recently Viewed Items