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Merck - 567732-10MG - Sphingosine Kinase 1 Inhibitor, SKI-178 | Calbiochem | 10 MG

  • MFR SKU: 567732-10MG
  • ITEM #: 11592181
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ITEM #: 11592181
Sphingosine Kinase 1 Inhibitor, SKI-178
| Calbiochem | 10 MG
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Merck - 567732-10MG - Sphingosine Kinase 1 Inhibitor, SKI-178 | Calbiochem | 10 MG

  • Item #: 11592181
  • MFR SKU: 567732-10MG
  • Overview A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (K i = 1.33 and >> 25 µ M, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC 50 in the range of 0.1-1.8 µ M).
  • Catalogue Number 567732
  • Brand Family Calbiochem®
  • Synonyms N-(1 E )-1-(3, 4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide
  • References Hengst, J.A., et al. 2010. .Bioorg. Med. Chem. Lett. 20, 7498
  • Form Off-white powder
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 92% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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