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Merck - 567735-10MG - Sphingosylphosphoryl-choline | CAS 1670-26-4 | Calbiochem | 10MG

  • MFR SKU: 567735-10MG
  • ITEM #: 6280501
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ITEM #: 6280501
Sphingosylphosphorylcholine^ (SPC; lyso-sphingomyelin). Light-yellow solid. PROTECT FROM MOISTURE. SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A.
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Merck - 567735-10MG - Sphingosylphosphoryl-choline | CAS 1670-26-4 | Calbiochem | 10MG

  • Item #: 6280501
  • MFR SKU: 567735-10MG
  • Overview SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca 2+ and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125 FAK ) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss/3T3 cells. Also induces a unique reorganization of the actin cytoskeleton.
  • Catalogue Number 567735
  • Brand Family Calbiochem®
  • Synonyms SPC, lyso -Sphingomyelin
  • References Berger, A., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 5885.
  • Dettbarn, C., et al. 1995. Brain Res. 669, 79.
  • Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343.
  • Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334.
  • CAS number 1670-26-4
  • ATP Competitive N
  • Form White solid
  • Hill Formula CHNOP
  • Chemical formula CHNOP
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target A potent mitogen
  • Purity ≥ 98% by TLC
  • Cell permeable N
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Moisture Protect from moisture
  • Do not freeze Ok to freeze
  • Special Instructions Following initial thaw, aliquot and freeze (-20° C). Stock solutions are stable for up to 2 months at -20° C.

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