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Merck - 567860-10MG - SRT1720 | CAS 925434-55-5 | Calbiochem | 10 MG

  • MFR SKU: 567860-10MG
  • ITEM #: 11575945
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ITEM #: 11575945
SRT1720, CAS 925434-55-5, is a cell-permeable inhibitor of the mitochondrial SIRT3. Inhibition is AceCS2-competitive (Ki = 0.56 µM; Km = 2.44 µM), but NAD+-uncompetitive (Ki = 0.34 µM; Km = 280 µM).
This listing is for 10 mg Glass bottle

Merck - 567860-10MG - SRT1720 | CAS 925434-55-5 | Calbiochem | 10 MG

  • Item #: 11575945
  • MFR SKU: 567860-10MG
Technical Specs
  • Overview A cell-permeable quinolinecarboxamide compound that is shown to inhibit the mitochondrial SIRT3 in a substrate AceCS2-competitive ( K i = 0.56 µ M; K m = 2.44 µ M), but NAD + -uncompetitive ( K i = 0.34 µ M; K m = 280 µ M), manner. Also reported to decrease cellular p53 Lys382 acetylation (Effective conc. = 10 µ M in U2OS and MEF cultures) and inhibit p300 HAT activity (IC 50 = 9 µ M) in vitro , as well as offer therapeutic benefits in several murine and rodent type 2 diabetes models (100 mg/kg/dayl p.o.) in vivo . Whether and how SRT1720 activates SIRT1 activity remains uncertain. Also available as a 25 mM solution in DMSO (Cat. No. 530748 ).
  • Catalogue Number 567860
  • Brand Family Calbiochem®
  • Synonyms N-(2-(3-(1-Piperazinylmethyl)imidazo[2, 1-b]thiazol-6-yl)phenyl)-2-quinolinecarboxamide, Sirtuin-3 Inhibitor, SRT1720, SIRT3 Inhibitor II, HAT Inhibitor XI, Histone Acetyltransferase Inhibitor XI, p300/CBP Inhibitor IX
  • References Baur, J.A., et al. 2012. Nat. Rev. Drug Discov. 11, 443.
  • Minor, R.K., et al. 2011. Sci. Rep. 1, 70.
  • Huber, J.L., et al. 2010. Future Med. Chem. 2, 1751
  • Pacholec, M., et al. 2010. J. Biol. Chem. 285, 8340
  • Jin, L., et al. 2009. Protein Sci. 18, 514
  • Feige, J.N., et al. 2008. Cell Metab. 8, 347
  • Milne, J.C., et al. 2007. Nature 450, 712.
  • CAS number 925434-55-5
  • Form Yellow solid
  • Hill Formula CHNO S
  • Chemical formula CHNO S
  • Structure formula Image
  • Quality Level MQ100
  • Application SRT1720, CAS 925434-55-5, is a cell-permeable inhibitor of the mitochondrial SIRT3. Inhibition is AceCS2-competitive (Ki = 0.56 µ M; Km = 2.44 µ M), but NAD+-uncompetitive (Ki = 0.34 µ M; Km = 280 µ M).
  • Purity ≥ 97% by HPLC
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Regulatory Review
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas
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