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Merck - 574102-5MG - Sulindac Sulfide | CAS 32004-67-4 | Calbiochem | 5MG

  • MFR SKU: 574102-5MG
  • ITEM #: 3449839
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ITEM #: 3449839
Sulindac Sulfide^ (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid. Purity >=98% by TLC. Soluble in DMSO and ethanol. CAS 32004-67-4. Yellow-orange solid. Molecular weight: 340.4. Harmful. May be carcinogenic/teratogenic. Inhibits Ras signaling.
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Merck - 574102-5MG - Sulindac Sulfide | CAS 32004-67-4 | Calbiochem | 5MG

  • Item #: 3449839
  • MFR SKU: 574102-5MG
  • Overview A cell-permeable, active metabolite of Sulindac (Cat. No. 574100 ). Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits growth and induces apoptosis in prostate cancer cell lines. Selectively inhibits COX-1 (ID 50 = 500 nM) compared to prostaglandin H synthase-2 (PGHS-2; COX-2; ID 50 = 14 µ M). Preferentially inhibits the secretion of Aβ 42 in CHO cells stably transfected with both APP 75 , and the PS1 mutant M146L.
  • Catalogue Number 574102
  • Brand Family Calbiochem®
  • Synonyms (Z)-5-Fluoro-2-methyl-1-[ p -(methylthio)benzylidene]indene-3-acetic Acid
  • References Weggen, S., et al. 2001. Nature 414, 212.
  • Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097.
  • Herrmann, C., et al. 1998. Oncogene 17, 1769.
  • Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105.
  • Arber, N., et al. 1997. Gastroenterology 113, 1892.
  • Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.
  • CAS number 32004-67-4
  • ATP Competitive N
  • Form Yellow-orange solid
  • Hill Formula CHFOS
  • Chemical formula CHFOS
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target COX-1 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> ID50 = 500 nM against COX-1
  • Purity ≥ 98% by TLC
  • Cell permeable Y
  • R Phrase R: 22-42/43-63
  • Harmful if swallowed.
  • May cause sensitization by inhalation and skin contact.
  • Possible risk of harm to the unborn child.
  • S Phrase S: 36
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Harmful & Carcinogenic / Teratogenic
  • Storage +15° C to +30° C
  • Do not freeze Ok to freeze

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