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Merck - 580222-10MG - Tau Aggregation Inhibitor, ATPZ, Cpd16 - Calbiochem

  • MFR SKU: 580222-10MG
  • ITEM #: 11575968
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$380.00
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ITEM #: 11575968
Tau Aggregation Inhibitor, ATPZ, Cpd16
, 10MG
This listing is for Each

Merck - 580222-10MG - Tau Aggregation Inhibitor, ATPZ, Cpd16 - Calbiochem

  • Item #: 11575968
  • MFR SKU: 580222-10MG
  • Overview A water soluble (32uM in water) BBB-permeable ATPZ (aminothienopyridazine) tau aggregation inhibitor that exhibited IC50 of 8.1uM in a heparin-induced tau assembly assay (monitored by thioflavine-T binding and fluorescence), and was further validated in vitro to reduce tau fibril formation (tau fragment K18PL, and full length tau40) by >50% in sedimentation assays. It also displayed very good B/P ratio (1.6) in a mice full PK study with good oral bioavailability and good metabolic stability. No cytotoxicity was observed at up to 100uM in HEK-293 cells.
  • Catalogue Number 580222
  • Brand Family Calbiochem®
  • Synonyms 5-amino-3-(4-chlorophenyl)-N-cyclopropyl-4-oxo-3, 4-dihydrothieno[3, 4-d]pyridazine-1-carboxamide
  • References Ballatore, C., et al. 2010. J. Med. Chem. 53, 3739.
  • Form Orange powder
  • Hill Formula CHClNOS
  • Chemical formula CHClNOS
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • Ship Code Shipped with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage -20° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.

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