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Merck - 5.00496.0001 - Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem

  • MFR SKU: 5.00496.0001
  • ITEM #: 13025340
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ITEM #: 13025340
Porcn Inhibitor II, C59
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Merck - 5.00496.0001 - Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem

  • Item #: 13025340
  • MFR SKU: 5.00496.0001
  • Overview A cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 (Cat. No. 681671 ) in inhibiting MBOAT family member Porcupine-mediated Wnt palmitoylation (IC 50 = 74 pM in STF reporter assays using Wnt3a-transfected HEK293). Shown to be effective against Porcn of murine and human, but not xenopus, species and potently inhibit the processing of both canonical and non-canonical Wnt subtypes. C59 is demonstrated to be orally active and effectively suppress MMTV-WNT1 tumor expansion in mice (5 mg/kg & 10 mg/kg p.o.) in vivo .
  • Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
  • Catalogue Number 500496
  • Brand Family Calbiochem®
  • Synonyms 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide, Wnt-C59, Wnt Pathway Inhibitor XVI
  • References Proffitt, K.D., et al. 2013. Cancer Res. 73, 502.
  • CAS number 1243243-89-1
  • Form Off-white powder
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible Y
  • Quality Level MQ100
  • Primary Target Porcupine (Porcn)-mediated Wnt palmitoylation
  • Purity ≥ 99% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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