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Merck - 5.00508.0001 - ATR Inhibitor III, ETP-46464 - CAS 1345675-02-6 - Calbiochem

  • MFR SKU: 5.00508.0001
  • ITEM #: 13025350
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ITEM #: 13025350
mTOR Inhibitor XIII, ETP-46464
This listing is for Each

Merck - 5.00508.0001 - ATR Inhibitor III, ETP-46464 - CAS 1345675-02-6 - Calbiochem

  • Item #: 13025350
  • MFR SKU: 5.00508.0001
Technical Specs
  • Overview A cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC 50 = 0.6, 14, 36, 170, and 545 nM, respectively) and preferentially suppresses radiation-induced cellular ATR activity (>90% at 500 nM) over ATM or DNA-PK activity (IC 50 > 5 µ M) in U2OS cells, while exhibiting much reduced or little potency toward a panel of 26 other kinases (>55% inhibition at 5 µ M). Shown to synergize with UCN-01 (Cat. No. 539644 ) in replicative stress induction in S-phase replicating U2OS (1.5-, 61-, and 190-fold of control RS, respectively, with 1 µ M ETP-46464, 50 nM UCN-01, or combined treatment).
  • Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
  • Catalogue Number 500508
  • Brand Family Calbiochem®
  • Synonyms 2-methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1, 3]oxazino[5, 4-c]quinolin-1(4H)-yl)phenyl)propanenitrile, ATM and Rad3-Related Inhibitor III, Ataxia-Telangiectasia Mutated Inhibitor III, DNA-PK Inhibitor VI, ATM Inhibitor III, mTOR Inhibitor XIII, PI 3-K Inhibitor XIX, ETP46464
  • References Thanasoula, M., et al. 2012. EMBO J. 31, 3398.
  • Toledo, L.I., et al. 2011. Nat Struct Mol Biol. 18, 721.
  • CAS number 1345675-02-6
  • Form White powder
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target ATR 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 14 nM
  • Purity ≥ 99% by HPLC
  • Cell permeable Y
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas
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