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Merck - 5.04712.0001 - -Catenin/Tcf Inhibitor VI, ICG-001 - CAS 847591-62-2 - Calbiochem

  • MFR SKU: 5.04712.0001
  • ITEM #: 13025416
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ITEM #: 13025416
This listing is for 10 mg Glass bottle

Merck - 5.04712.0001 - -Catenin/Tcf Inhibitor VI, ICG-001 - CAS 847591-62-2 - Calbiochem

  • Item #: 13025416
  • MFR SKU: 5.04712.0001
  • Overview A cell-permeable pyrazinopyrimidinecarboxamide that competes against β-catenin for CBP (CREB-binding protein) binding and selectively prevents CBP- but not p300-, dependent TCF/β-catenin transcriptional regulations both in cultures in vitro (5 to 25 µ M) and in mice in vivo (5 mg/kg/day via osmotic pump infusion), while not affecting CBP-dependent transcriptional activities mediated by the AP-1 or CRE complex. Shown to reactivate p300//TCF/β-catenin-mediated neuronal differentiation upon NGF stimulation in PS-1 L286V mutant-expressing PC-12 cultures and be efficacious in alleviating bleomycin- (0, 08 units/50 µ L/mouse; administered intranasally; Cat. No. 203401 ) induced pulmonary fibrosis in mice.
  • Catalogue Number 504712
  • Brand Family Calbiochem®
  • Synonyms ICG001, Wnt Pathway Inhibitor XX, (6 S , 9a S )-Hexahydro-6-((4-hydroxyphenyl)methyl)-8-(1-naphthalenylmethyl)-4, 7-dioxo-N-(phenylmethyl)-2H-pyrazino[1, 2-a]pyrimidine-1(6H)-carboxamide, (6 S )-N-Benzyl-6-(p-hydroxyphenylmethyl)-8-(1-naphthylmethyl)-4, 7-dioxohexahydro-2H-pyrazino[1, 2-a]pyrimidine-1-carboxamide
  • References Yan, D., et al. 2012. J. Biol. Chem. 287, 8598.
  • Henderson, W.R. Jr, et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 14309.
  • Eguchi, M., et al. 2005. Med Chem. 1, 467.
  • Ma, H., et al. 2005. Oncogene. 24, 3619.
  • Teo, J.L., et al. 2005. Proc. Natl. Acad. Sci. USA. 102, 12171.
  • Emami, K.H., et al. 2004. Proc. Natl. Acad. Sci. USA. 101, 12682.
  • CAS number 847591-62-2
  • Form Off-white powder
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target CREB-binding protein
  • Purity ≥ 99% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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