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Merck - 5.05758.0001 - Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem

  • MFR SKU: 5.05758.0001
  • ITEM #: 13025508
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ITEM #: 13025508
This listing is for 25 mg Glass bottle

Merck - 5.05758.0001 - Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem

  • Item #: 13025508
  • MFR SKU: 5.05758.0001
  • Overview A 2′, 3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X 7 purinergic receptors in J774 mouse macrophages. Does not affect P2 γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X 7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca 2+ influx in lymphocytes (˜ 100 µ M). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
  • Catalogue Number 505758
  • Brand Family Calbiochem®
  • Synonyms Purinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP
  • References Vergani, A., et al. 2013. Diabetes 62, 1665.
  • DellAntonio, G., et al. 2002. Arthritis Rheum. 46, 3378.
  • Wiley, J.S., et al. 1994. Br. J. Pharmacol. 112, 946.
  • Murgia, M., et al. 1992. J. Biol. Chem. 268, 8199.
  • CAS number 71997-40-5
  • Form White powder
  • Hill Formula CHNOP
  • Chemical formula CHNOP
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target P2X
  • Purity ≥ 97% by HPLC
  • Ship Code Shipped with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.

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