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Merck - 5.05981.0001 - PK11195 - CAS 85532-75-8 - Calbiochem

  • MFR SKU: 5.05981.0001
  • ITEM #: 13025533
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ITEM #: 13025533
This listing is for 10 mg Glass bottle

Merck - 5.05981.0001 - PK11195 - CAS 85532-75-8 - Calbiochem

  • Item #: 13025533
  • MFR SKU: 5.05981.0001
  • Overview An isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (K d = 20 nM). Exhibits anti-inflammatory properties. Binds to monocytes and following lesioning its binding up-regulated in brain macrophages and activated microglia. Shown to enhance the susceptibility of cells to apoptosis induction by DNA damaging agents and can reverse the suppression of apoptosis by Bcl-2. Serves as a ligand of the outer membrane translocator protein and reduces mitochondrial transmembrane potential within 30 minutes of exposure (˜ 100 µ M).
  • Catalogue Number 505981
  • Brand Family Calbiochem®
  • Synonyms Mitochondrial Translocator Protein Activator II, PK 11195, PK-11195, TSPO Activator II, PK11195
  • References Naoi, M., et al., 2013. J. Neural Transm. In press
  • Casellas, P., et al., 2002. Neurochem. Int. 40, 475.
  • Waterfield, J.D., et al., 1999. Rheumtology 38, 1068.
  • CAS number 85532-75-8
  • Form White solid
  • Hill Formula CHClNO
  • Chemical formula CHClNO
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target peripheral bezodiazepine receptor i $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target K i " value=" Biological Information"
  • br> Primary Target K<sub>i</sub> 20 nM
  • Purity ≥ 98% by HPLC
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.

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