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Merck - 5.06419.0001 - Methysergide Maleate - CAS 129-49-7 - Calbiochem

  • MFR SKU: 5.06419.0001
  • ITEM #: 13025555
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ITEM #: 13025555
This listing is for 10 mg Glass bottle

Merck - 5.06419.0001 - Methysergide Maleate - CAS 129-49-7 - Calbiochem

  • Item #: 13025555
  • MFR SKU: 5.06419.0001
  • Overview An antagonist of the 5-HT 2B (pki = 8.0-9.4) and 5-HT 2C (pki = 8.6-9.1) receptor. At the 5-HT 1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC 50 = 18 µ M. Originally developed in the 1960′s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT 2 receptor antagonist in both in vivo and in vitro experiments.
  • Catalogue Number 506419
  • Brand Family Calbiochem®
  • Synonyms 5-HT Serotonin Receptor Antagonsit, Methysergide Maleate, UML-491
  • References Matsuta, Y. et al. 2013. Exp. Neurol. 247, 250.
  • IUHPAR Database 2013.
  • Shad, K.F., Saeed, S.A. 2007. Exp. Brain Res. 183, 411.
  • Knight, A.R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
  • Saxena, P.R and Lawang, A. 1985. Arch. Int. Pharmacodyn. Ther. 277, 235.
  • Colpaert, F. C. et al. 1979. Eur. J. Pharmacol. 58, 505.
  • CAS number 129-49-7
  • Form Off-white solid
  • Hill Formula CHNO· CHO
  • Chemical formula CHNO· CHO
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target 5-HT
  • Purity ≥ 99% by HPLC
  • R Phrase R: 25
  • Toxic if swallowed.
  • S Phrase S: 36/37/39-46
  • Wear suitable protective clothing, gloves and eye/face protection.
  • If swallowed, seek medical advice immediately and show this container or label.
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Toxic
  • Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.

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